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Structural and biochemical
properties
of amino acids;
protein structure and
thermodynamics
of polypeptide chain folding; protein purification and
characterization; catalytic mechanisms, kinetics and
regulation of
enzymes; energetic of biochemical
reactions; metabolism; roles of coenzymes and prosthetic groups in
redox
reactions; pathways for carbohydrate oxidation; glycogen metabolism;
glucose
synthesis; tricarboxylic acid cycle, electron transport and oxidative
phosphorylation.
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Structure and functional
properties
of biological lipids (glycerolipids, phospholipids, ceramides,
glycolipids, waxes, terpenes and steroids); membrane organization;
membrane proteins and transport processes across cell membrane;
regulation of lipid metabolism; biosynthesis, breakdown and
interconversion of fatty acids, cholesterol, isoprenoids and
eucosonoids; hormone action, integration of metabolism, organ
specialization, and metabolic disorders.
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Examination of microbe-host cell interactions from cell
biology perspective; highlights the notion that microbial symbiosis
is fundamental in evolution, physiology and development, and
coexistence and cooperative
associations are important along with natural selection.
Particular emphasis is given to understanding
the dynamic equilibrium of human microbiome, ecological and
evolutionary
significance of human-microbe interactions and how the composition and
diversity of microbial
communities inhabiting mucosal surfaces of the human body are involved
in
health and diseases. Topics include
bacterial
virulence, toxins, intracellular parasitism, subversion of host cell
functions,
cellular responses, innate and acquired immunity, inflammation,
antimicrobial
therapy, vaccines, microbial genomics and proteomics applications in
medical
microbiology
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Nutrition and Metabolism examines nutrient utilization and
requirements with an emphasis on multifaceted links between diet, health,
genetics, microbiome, and diseases. Topics cover the basis of
metabolic homeostasis and nutritional physiological phenomena in the context of
changing requirements, such as during development, aging, exercise, and various
disease conditions. The role of macronutrients and major vitamins and minerals
in energy metabolism as well as benefits of potentially-protective plants
compounds in food is reviewed. How unbalanced intake of nutrients
contributes to the initiation, development and severity of chronic diseases are
discussed with relevance to clinical nutrition. Nutritional characteristics of
diets are examined in the context of human evolution and behavioral, societal
and ecological interactions. Interconnected
problems involving public health, sustainable food, nutrition security,
agriculture and the food industry are discussed. The course also introduces
microbiomics, nutrigenomics, nutrigenetics and chrononutrition to explore
evolving concepts concerning gene-nutrient interactions, particularly the influence
of diet on intestinal microbiota and the effect of food and sleep on
metabolism.
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Structural organization of
eukaryotic cells; regulation
of cellular activities; membranes and transport across cell membrane;
cell
specialization; cell signaling molecules and cell surface receptors;
signal
transduction pathways that control gene activity; the organization and
control
of the eukaryotic cytoskeleton; mechanisms of protein targeting to
cellular
organelles; vesicle traffic, secretion and endocytosis; the molecular
regulation of the eukaryotic cell cycle, and aspects of the molecular
basis of
cancer.
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Applications of biotechnology
methods in a laboratory
setting; isolation and analysis of DNA, proteomics (theories and
concepts
related to research and clinical studies, 1D and 2D SDS PAGE, liquid
chromatography, instrumentation basics of mass spectrometry, ionization
techniques, peptide fragmentation, peptide fingerprinting, and protein
identification and bioinformatics applications for protein sequence
analysis
and BLAST Searching), real time PCR, ELISA, FACS cell sorting,
transfection of
animal cells, immunocytochemistry and confocal microscopy.
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Introduction to fundamental
concepts in biology with an
emphasis on the molecular and cellular organizations of cells and
mechanisms
associated with biological phenomena. Topics include the chemistry and
metabolism of biological molecules, classical and molecular genetics,
selected
aspects of developmental biology, as well as study of major groups of
biological organisms such as bacteria, viruses and fungi.
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Fundamentals of mammalian
physiology with an emphasis on the
human body systems, organ development, regulation of organ functions
and
regulation of internal environment (homeostasis).
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Introduction of incoming
freshmen to the intellectual and
cultural environment of the School of Natural Science and Mathematics
(NS&M). Students learn about
plans
of study and career paths for majors in Biology, Chemistry, Physics,
Mathematics, Geosciences, and Science and Mathematics Education. Approaches to basic study and learning
strategies, critical thinking, problem solving and group-work as well
as
studentship and professional ethics needed to succeed as an NS&M
major will
be reviewed. Students will study the
connections within the disciplines of NS&M, as well as their
relationship
to medicine, health and other scientific, technology and engineering
fields.
Emphasis is given to discussions on current and emerging themes of
scientific
research, education and interdisciplinary technology applications in
the 21st
century.
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Introductory to human
physiology in relation to
molecular, cellular and anatomical structures; examination of human
body and
organ systems with model-based lab exercises; physiological functions
associated with homeostasis and integration of metabolism, basic
information
about diseases and disorders with special considerations to
preventative and
self-care approaches.
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Planning and conducting thematic
research; strategies for
analyzing scientific literature, examining original research articles,
communicating facts and theories by coherent writing.
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BIOL
5V00 - INTRODUCTION TO
BIOTECHNOLOGY
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Overview of techniques utilized in
biomedical research and
bioprocessing/biomanufacturing applications in the pharmaceutical,
agricultural
and environmental biotechnology industries;
principles of methods involving protein chemistry, molecular and cell
biology; macromolecular separation, detection and assay methods, DNA
sequencing, recombinant DNA, protein engineering, amplification and
hybridization-based
methods, genotyping, gene expression analysis, microarrays,
bioinformatics,
genomics, proteomics, and systems biology-based approaches.
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