Comet Calendar, The Official Event Calendar for UT Dallas en-us This week's events for Natural Sciences & Mathematics at UT Dallas Biological Sciences 2016 Spring Seminar Series Presents: Dr. Zhaolan "Joe" Zhou, "Epigenetic Control of Genome Function: Insight from Mouse Models of Rett Syndrome". Thursday, Feb 11
(4 p.m.)

DNA methylation is a classical epigenetic mark that plays a critical role in genome stability, maintenance and function. A family of methyl-CpG binding domain proteins (MBDs), including MBD1, MBD2, MBD4 and MeCP2, has been identified to bind to DNA in a methylation density-dependent manner and recruit chromatin modifiers to modulate gene transcription. The critical role of these MBDs in the etiology of autism spectrum disorders has been supported by human genetic studies, as mutations in MBD1 and MBD4 are linked to autism and mutations in MeCP2 are responsible for Rett syndrome, a neurodevelopmental disorder with autistic features. How each individual MBD interprets DNA methylation and how mutations in MBDs selectively impair brain function remain poorly understood. This seminar will focus on mouse genetic studies of Rett syndrome and discuss a role for MeCP2 in regulating genome function.

Statistics Colloquium by Hon Keung Ng Friday, Feb 12
(2 p.m. - 3 p.m.)

Hon Keung Ng

Department of Statistical Science, SMU

Analysis of System-based Reliability Data

Sponsored by the Department of Mathematical Sciences

Physics Colloquium: Physical Cues for Axonal Guidance Wednesday, Feb 17
(4 p.m. - 5 p.m.)

Dr. Samarendra Mohanty (NanoScope Technologies)

The establishment of functional connections via axonal pathfinding is dynamic in nature and continues from neurogenesis until adulthood. While advancement has been made in understanding axonal guidance by different chemical cues, there has been a lack of understanding if and how axons respond to physical cues. I will present how different physical cues such as force, flow, and heat etc can be used to guide axons with varying efficacy. These cues can be very effectively generated by photonic means in a spatio-temporally localized and controlled manner. Use of these optical guidance technologies to unravel unique properties of axons will be presented.