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School of Behavioral and Brain Sciences - The University of Texas at Dallas

Jonathan Ploski

 

Jonathan Ploski

Assistant Professor

PhD, Mount Sinai School of Medicine

Molecular and Biochemical Mechanisms of Synaptic Plasticity, Emotional Learning and Memory

 

NSERL 1.414

972-883-2014 phone

jonathan.ploski@utdallas.edu email

 

Ploski Lab website

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research Interests

 

My research interests are directed toward elucidating the molecular and cellular mechanisms of neuronal plasticity that govern emotional memory as well as identifying the causes and consequences of aberrant forms of plasticity that occur in psychiatric disorders, such as anxiety. Collectively my research utilizes a myriad of molecular, biochemical and behavioral approaches.

 

Some of the ongoing projects in my laboratory are:

 

  • Identification of transcripts that localize to dendrites following synaptic activity
  • Investigating emotional learning & memory aberrations within an environmentally induced animal model of autism at the behavioral and molecular levels
  • Determining the Adeno-Associated Viral (AAV) serotypes that are optimal for transducing excitatory and inhibitory neurons within amygdala nuclei critical for emotional learning & memory
  • Identifying the molecular mechanisms that promote/inhibit memory stabilization/destabilization following memory retrieval

 

Specialties: Pavlovian fear conditioning, memory consolidation and reconsolidation, AAV and Lenti virus production for in vivo delivery of recombinant transgenes, Gene expression analysis, Gene identification

 

Recent Publications

 

Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala. Holehonnur R, Luong JA, Chaturvedi D, Ho A, Lella SK, Hosek MP, Ploski JE. BMC Neurosci. 2014 Feb 18;15(1):28. doi: 10.1186/1471-2202-15-28.

 

Amygdala nuclei critical for emotional learning exhibit unique gene expression patterns. Partin AC, Hosek MP, Luong JA, Lella SK, Sharma SA, Ploski JE. Neurobiol Learn Mem. 2013 Sep;104:110-21. doi: 10.1016/j.nlm.2013.06.015. Epub 2013 Jul 2.

 

The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. Ploski JE, Monsey MS, Nguyen T, DiLeone RJ, Schafe GE. PLoS One. 2011;6(8):e23760. doi: 10.1371/journal.pone.0023760. Epub 2011 Aug 22.

 

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