Physiology of the prefrontal cortex as it relates to schizophrenia and drug addiction
Dr. Sven Kroener is known for his research into animal models of schizophrenia and drug addiction. One line of inquiry in his lab investigates behavioral and electrophysiological changes in the prefrontal cortex that occur in a developmental model of schizophrenia which uses NMDA receptor antagonism to affect the function of GABAergic interneurons. Other projects look at vagus nerve stimulation (VNS) as a tool to increase extinction from drug seeking and to prevent relapse, and how alcohol addiction affects cognitive flexibility. All of these projects use a combination of behavioral, electrophysiological, and immunohistochemical techniques. The current work in Dr. Kroener’s lab expands on his previous research which examined dopamine modulation of prefrontal cortical networks and the role of interneurons in schizophrenia and drug addiction. Dr. Kroener is currently the principal investigator or co-investigator on three grants from the National Institutes of Health and the UT Brain Initiative, and he was previously responsible for four different extramural and intramural grants from NIH and UTD. Dr. Kroener earned his master’s and doctoral degrees at the Ruhr-University in Bochum, Germany.
Recent Articles in Peer-Refereed Journals
Childs JE, DeLeon J, Nickel E, Kroener S. Vagus nerve stimulation reduces cocaine-seeking and alters plasticity in the extinction network. Learning Mem. (in press).
Holehonnur R, Phensy A, Kim L, Milivojevic M, Vuong D, Daison D, Alex S, Tiner M, Jones L, Kroener S, Ploski J (2016) Increasing the GluN2A/GluN2B ratio in neurons of the mouse basal and lateral amygdala inhibits the modification of an existing fear memory trace. J Neurosci 36(36): 9490-9504; doi: 10.1523/JNEUROSCI.1743-16.2016.
Beck SJ, Guo L, Phensy A, Tian J, Wang L, Tandon N, Gauba E, Lu L, Pascual J, Kroener S, Du H (2016) Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nature Communications 7:11483. doi:10.1038/ncomms11483.
Childs JE, Alvarez AC, McIntyre CK, Kroener S (2015) Vagus nerve stimulation as a tool to induce plasticity in pathways relevant for extinction learning. JoVE — Journal of Visualized Experiments. 102. doi: 10.3791/53032. PMID: 26325100.
Hu, W., Morris, B., Carrasco, A., Jeevakumar, V., Kroener, S (2015). Effects of acamprosate on attentional set-shifting and cellular function in the prefrontal cortex of chronic alcohol-exposed mice. Alcohol: Clinical and Experimental Research, 39(6):953-61. doi: 10.1111/acer.12722. PMID: 25903298.