Mehmet Candas
utd
Mehmet Candas  
BIOGRAPHY TEACHING RESEARCH VIEWPOINT CONTACT

Mehmet Candas is a scientist, educator and occasional multimedia artist at The University of Texas at Dallas. He teaches at the School of Natural Sciences and Mathematics, including courses in Biochemistry, Molecular Cell Biology, Biotechnology, Proteomics, Cellular Microbiology, Modern Biology, and Human Body Systems.  Previously he served as Research Manager at the Center for Biotechnology and Bioinformatics and conducted research on cell adhesion receptors and insecticidal action of bacterial toxins.  He also helped establish an agricultural and environmental biotechnology company.  As a scientific co-founder and internal consultant, he provided strategic and operational leadership for R&D projects and implemented a technology platform for genomic-based product development.  The platform integrated bioinformatics and proteomics applications with laboratory robotics, enabling selection of gene-specific primers through processing of multi-species genetic sequences.  The technology facilitated high-throughput cloning and construction of gene libraries utilized to identify expression-ready cDNA clones and generated cell-based functional assays for drug and insecticide chemistry screening.

Prior to UT-Dallas, Dr. Candas was at Cytoclonal Pharmaceutics.  At this position, he worked on development of recombinant protein expression vectors and live bacteria vaccine delivery technologies for immune stimulation and treatment of infectious diseases and cancer.  Before coming to the U.S., Dr. Candas was a faculty member in Ankara University, School of Medicine (Türkiye) where he taught Medical Biology and Clinical Genetics.  Prior that, he worked at Düzen Laboratories, an established company for medical technology and molecular diagnostics services specializing in clinical biochemistry, microbiology and medical imaging.

Dr. Candas earned his PhD degree from Southern Methodist University (Dallas, Texas) and MS and BS degrees from Middle East Technical University (Ankara, Türkiye) with specialties in molecular genetics, biochemistry and microbiology.  In his doctoral dissertation, he studied antioxidant defenses and the aging process.  He characterized the glutathione/thioredoxin reductase gene in Drosophila melanogaster.  His work set the stage for overexpression of the gene in transgenic Drosophila and facilitated understanding its role in survival extension under oxidative stress.  His Master's thesis covered studies on RNA modifications in cancer.  He studied differences in transfer RNA populations between normal tissues and tumors in human brain cancers.  His postdoctoral work involved studies in bacterial metabolism and virulence regulation.  He investigated propionate metabolism and biofilm production in Pseudomonas aeruginosa and identified molecular targets suitable for development of new anti-infectives.  His current research interests focus on intracellular signaling pathways associated with cell adhesion receptors, and bacteria and insect systems as paradigms for microbe-host interactions.  He studies structural and functional aspects of adhesion receptors and cell death signaling cascades with the goal of understanding regulatory pathways involved in development, and determining biochemical mechanisms of microbial toxins, drugs and insecticide action.  His studies suggest broad implications for the involvement of gut epithelium in physiological responses, and provide new insight into the genetic basis of cellular resistance to stress.

Dr. Candas completed a wide spectrum of projects spanning from research studies in aging, cancer and infectious diseases to development of biotechnology products involving drug discovery, DNA vaccines, crop protection, bioremediation and soil improvement.  His accomplishments have been described in several patents and journal articles, and he has been a featured speaker at scientific meetings and industry trade conferences.  Dr. Candas lives in vibrant Dallas.


BIOGRAPHY TEACHING RESEARCH VIEWPOINT CONTACT

© 2014  |  Mehmet Candas  |  Biological Sciences  |  The University of Texas at Dallas