Journal Publications

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MicroRNA circuits for transcriptional logic.
Leisner, M., L. G. Bleris, J. Lohmueller, Z. Xie, Y. Benenson.
Methods in Molecular Biology, Volume 813, Part 2, 2012

Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template.
Bleris, L. G., Z. Xie, D. Glass, A. Adadey, E. Sontag, Y. Benenson
Nature/EMBO Molecular Systems Biology 7, 2011.

Linear control theory for gene network modeling.
Shin Y. J. and L. G. Bleris.
PLoS One, 5(9), 2010.

Rationally designed logic integration of regulatory signals in mammalian cells.
Leisner, M., L. G. Bleris, J. Lohmueller, Z. Xie, Y. Benenson.
Nature Nanotechnology 5, 666–670, 2010.

Logic integration of mRNA signals by an RNAi-based molecular computer.
Xie, Z., S. J. Liu, L. G. Bleris and Y. Benenson.
Nucleic Acids Research 38(8):2692-701. 2010.

A System-on-a-Chip Implementation for Embedded Real-Time Model Predictive Control.
Vouzis, P. D., L. G. Bleris, M. G. Arnold, M. V. Kothare.
IEEE Transactions on Control Systems Technology, 17:5, 1006-1017, 2009.

Molecular Circuits for Information Processing in Human Cells.
Bleris, L. G.
Bio 24, 42-46, 2008

A universal RNAi-based logic evaluator that operates in mammalian cells.
Rinaudo, K.*, L. G. Bleris*, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson.
Nature Biotechnology 25, 795-801, 2007
(*equal contribution)

Pathways for Optimization-based Drug Delivery Systems and Devices.
Bleris, L. G., P. D. Vouzis, J. G. Garcia, M. G. Arnold, M. V. Kothare.
Control Engineering Practice, Volume 15, Issue 10, October 2007, Pages 1280-1291

Model Predictive Hydrodynamic Regulation of Microflows.
Bleris, L. G., J. G. Garcia, M. G. Arnold., M. V. Kothare.
Journal of Micromechanics and Microengineering, 16, 1792-1799, 2006.

Towards Embedded Model Predictive Control for System-On-a-Chip Applications.
Bleris, L. G., J. G. Garcia, M. V. Kothare, M. G. Arnold.
Journal of Process Control, 16, 255-264, Mar. 2006.

Reduced Order Distributed Boundary Control of Thermal Transients in Microsystems.
Bleris, L. G. and M. V. Kothare.
IEEE Transactions on Control Systems Technology, 13:6, 853-867, 2005.

Low-Order Empirical Modeling of Distributed Parameter Systems Using Temporal and Spatial Eigenfunctions.
Bleris, L. G. and M. V. Kothare.
Computers & Chemical Engineering, 29, 817-827, 2005.

Conferences/Presentations

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Simulating Transient Delivery of Three-Node Feedforward Networks.
Bhuiyan, T. and L. G. Bleris.
The Southern Biomedical Engineering Conference, Arlington, Texas, April 2011.

Characterization of Nonlinear Feedback using a Synthetic Circuit in Human Cells.
White, J. and L. G. Bleris.
The Southern Biomedical Engineering Conference, Arlington, Texas, April 2011.

A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells.
Bleris, L. G., Z. Xie, E. Sontag, Y. Benenson.
AIChE annual meeting, Salt Lake City Utah, November 2010.

Novel Statechart and Control Theory Based Approaches for Gene Network Modeling.
Shin Y. J., Nourani, M. and L. G. Bleris.
AIChE annual meeting, Salt Lake City Utah, November 2010.

Parametric Simulations Reveal Steady-State Properties of Feedforward-Loop Motifs.
White, J. and L. G. Bleris.
AIChE annual meeting, Salt Lake City Utah, November 2010.

Modeling complex gene networks using control theory.
Shin Y. J. and L. G. Bleris.
SDPS-2010, Dallas,TX, June, 2010.

Rational design and implementation of complex transcriptional logic in mammalian cells.
Leisner M., L. G. Bleris, J. Lohmueller, Z. Xie, Y. Benenson.
Annual Conference of Institute of Biological Engineering, Cambridge, MA, March 2010.

Nanotechnology for Reverse Engineering of Biological Pathways.
Skarmoutsou, A., L. G. Bleris, and C.A. Charitidis.
International Conference Instrumental Methods of Analysis-Modern Trends and Applications, Athens, Greece, Oct 2009.

Transcriptional feed-forward motif as stable expression unit.
Bleris, L. G., Z. Xie, A. Adadey, E. Sontag, Y. Benenson.
Systems Biology of Human Disease 2009, Boston, MA, June 2009.

Design and Optimization of an RNAi Based Biomolecular Logic Circuit.
Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson.
AIChE annual meeting, Philadelphia, PA, November 2008.

A Universal Logic Evaluator that Operates in Mammalian Cells.
Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson.
4th International Greek Biotechnology Forum, Athens, Greece, May 2008.

An in Vivo General Purpose Molecular Logic Evaluator.
Bleris, L. G., K. Rinaudo, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson.
AIChE annual meeting, Salt Lake City, UT, November 2007.

A Co-Processor FPGA Platform for the Implementation of Real-Time Model Predictive Control.
Bleris, L. G., P. D. Vouzis, M. G. Arnold, M. V. Kothare.
American Control Conference 2006, Minneapolis, Minnesota, July 2006.

Towards Embedded Model Predictive Control for System-On-a-Chip Applications.
Bleris, L. G., J. G. Garcia, M. V. Kothare, M. G. Arnold.
Journal of Process Control, 16, 255-264, Mar. 2006.

Implementation of Model Predictive Control for Glucose Regulation using a General Purpose Microprocessor.
Bleris, L. G. and M. V. Kothare.
44th IEEE Conference on Decision and Control and European Control Conference ECC 2005, Seville, Spain, December 2005.

Reduced Order Distributed Boundary Control of Thermal Transients in Microsystems.
Bleris, L. G. and M. V. Kothare.
IEEE Transactions on Control Systems Technology, 13:6, 853-867, 2005.

Low-Order Empirical Modeling of Distributed Parameter Systems Using Temporal and Spatial Eigenfunctions.
Bleris, L. G. and M. V. Kothare.
Computers & Chemical Engineering, 29, 817-827, 2005.

Entropy of Spatiotemporal Data as a Dynamic Truncation Indicator for Model Reduction Applications.
Bleris, L. G. and M. V. Kothare.
American Control Conference, Pages: 3145-3150, Portland, OR, June 2005.

Embedded Model Predictive Control for System-On-a-Chip Applications.
Bleris, L. G., Kothare, M. V., Garcia, J. and M. G. Arnold.
7th International Symposium on Dynamics and Control of Process Systems, Boston, MA, July 2004.

Finite Element Method Simulations of Microchannels for Control and Reduced Order Modeling Applications.
Bleris, L. G. and M. V. Kothare.
Proceedings of Mathematics and Informatics for Industry Conference, Pages: 162-169 Thessaloniki, Greece, April 2003.